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Understanding depression: the hippocampus might hold the answer in a CREB ‐regulated transcription coactivator
Author(s) -
Davis Randall L.
Publication year - 2019
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14659
Subject(s) - creb , coactivator , transcription factor , mediator , neuroscience , neurochemistry , cyclic adenosine monophosphate , hippocampus , neuroinflammation , depression (economics) , psychology , medicine , chemistry , neurology , receptor , biochemistry , inflammation , gene , macroeconomics , economics
The pathophysiology of major depressive disorders is not completely understood. In this issue of Journal of Neurochemistry, Ni and colleagues investigate the role of cyclic adenosine monophosphate response element‐binding protein (CREB)‐dependent signaling in the hippocampus on depressive‐like behaviors. This editorial highlights the key findings reported by Ni et al., (2018) and how they demonstrated the importance of CREB‐regulated transcription cofactor 1 in LPS‐induced neuroinflammation and depressive‐like behaviors.