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Genetic and epigenetic contribution to astrocytic gliomas pathogenesis
Author(s) -
Khani Pouria,
Nasri Farzad,
Khani Chamani Fateme,
Saeidi Farzane,
Sadri Nahand Javid,
Tabibkhooei Alireza,
Mirzaei Hamed
Publication year - 2019
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14616
Subject(s) - epigenetics , pathogenesis , biology , glioma , identification (biology) , disease , epigenesis , pathology , neuroscience , gene , genetics , dna methylation , medicine , immunology , gene expression , botany
Astrocytic gliomas are the most common and lethal form of intracranial tumors. These tumors are characterized by a significant heterogeneity in terms of cytopathological, transcriptional, and (epi)genomic features. This heterogeneity has made these cancers one of the most challenging types of cancers to study and treat. To uncover these complexities and to have better understanding of the disease initiation and progression, identification, and characterization of underlying cellular and molecular pathways related to (epi)genetics of astrocytic gliomas is crucial. Here, we discuss and summarize molecular and (epi)genetic mechanisms that provide clues as to the pathogenesis of astrocytic gliomas.