Premium
Proteomics of neurodegenerative diseases: analysis of human post‐mortem brain
Author(s) -
Li K. W.,
Ganz Andrea B.,
Smit August B.
Publication year - 2019
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14603
Subject(s) - proteomics , amyotrophic lateral sclerosis , frontotemporal dementia , dementia , disease , biomarker , proteome , neuroscience , alzheimer's disease , medicine , bioinformatics , biology , pathology , biochemistry , gene
Dementias are prevalent brain disorders in the aged population. Dementias pose major socio‐medical burden, but currently there is no cure available. Novel proteomics approaches hold promise to identify alterations of the brain proteome that could provide clues on disease etiology, and identify candidate proteins to develop further as a biomarker. In this review, we focus on recent proteomics findings from brains affected with Alzheimer's Disease, Parkinson Disease Dementia, Frontotemporal Dementia, and Amyotrophic Lateral Sclerosis. These studies confirmed known cellular changes, and in addition identified novel proteins that may underlie distinct aspects of the diseases.This article is part of the special issue "Proteomics".