Issue Cover (December 2019)

Front cover: Ischemic preconditioning (IPC) could induce neuron ischemic tolerance. However, the mechanism is not very clear. This study explores whether PPARγ participates in the induction of neuron ischemic tolerance by IPC via regulating GLT‐1. At first, we found that cerebral IPC up‐regulated PPARγ and GLT‐1 expressions in astrocytes in CA1 hippocampus, and induced neuron ischemic tolerance in rats. Then the molecular mechanism of PPARγ contributed to neuroprotection induced by IPC through regulating GLT‐1 was verified in astrocyte‐neuron co‐cultures. Inhibiting PPARγ by its selective antagonist T0070907 or PPARγ siRNA significantly attenuated GLT‐1 up‐regulation and neuroprotection induced by IPC. Consistently, pre‐administration of T0070907 inhibited GLT‐1 up‐regulation and neuron ischemic tolerance induced by cerebral IPC in rats. In conclusion, it reveals that PPARγ participates in the acquisition of neuron ischemic tolerance induced by IPC via regulating GLT‐1. Image content: The image is a representative photograph of thionin staining showing the histological change in CA1 hippocampus at 7d after brain ischemic insult. This image shows that ischemic insult, global brain ischemia for 8min, led to obvious neuronal death, which appeared neuronal pyknosis in CA1 hippocampus.Read the full preface ‘Peroxisome proliferator‐activated receptor gamma participates in the acquisition of brain ischemic tolerance induced by ischemic preconditioning via glial glutamate transporter 1 in vivo and in vitro’ by C‐C. Zhao, M‐Y. Jiang, L‐Y. Zhang, Y‐Y. Hu, Z‐J. Hu, M‐Y. Zhang, J. Qi, A‐C. Su, N. Lou, X‐H. Xian, J‐G. Zhang, W‐B. Li, M. Zhang ( J. Neurochem . 2019, vol. 151 (5), pp. 608–625) on doi: 10.1111/jnc.14824