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Issue Cover (July 2019)
Publication year - 2019
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14514
Subject(s) - neurotoxicity , astrocyte , cover (algebra) , neuroprotection , citation , neuroscience , humanities , medicine , philosophy , psychology , computer science , library science , toxicity , mechanical engineering , engineering , central nervous system
Front cover: The effects of oligomeric species of α‐synuclein (αSO), neurotoxins of Parkinson's disease (PD), on astrocytes have not been directly addressed. Here, by using an early model of PD, we showed that αSO induced astrocyte reactivity and enhanced the synaptogenic capacity of human and murine astrocytes by increasing the levels of transforming growth factor beta 1 (TGF‐β1). Our study describes a new neuroprotective role of astrocytes against the neurotoxicity induced by αSO and sheds light on the cellular and molecular mechanisms of synaptic changes in the early stages of PD. Image content: Confocal microscopy of cultured mesencephalic astrocytes immunolabeled for GFAP (red immunofluorescent staining) and human alpha synuclein, α‐Syn, (green immunofluorescent staining). Nuclei are shown in blue (Dapi signal). α‐Syn immunolabeling is observed extracellularly, on astrocyte's surface, and intracellularly, on astrocyte's cytoplasm.Read the full article ‘α‐synuclein oligomers enhance astrocyte‐induced synapse formation through TGF‐β1 signaling in a Parkinson's disease model’ by L. P. Diniz, I. Matias, A. P. B. Araujo, M. N. Garcia, F. G. Q. Barros‐Argão, S. V. Alves‐Leon, J. M. de Souza, D. Foguel, C. Pinto Figuiredo, C. Braga, L. Ramão, F. C. A. Gomes ( J. Neurochem . 2019, vol. 150 (2), pp. 138–157) on doi: 10.1111/jnc.14710