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Calcium/calmodulin‐dependent kinase II and memory destabilization: a new role in memory maintenance
Author(s) -
Vigil Fabio Antonio,
Giese Karl Peter
Publication year - 2018
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14454
Subject(s) - memory consolidation , calmodulin , neuroscience , association (psychology) , memory formation , protein kinase a , psychology , calcium signaling , calcium , kinase , biology , chemistry , microbiology and biotechnology , signal transduction , hippocampus , organic chemistry , psychotherapist
In this review, we discuss the poorly explored role of calcium/calmodulin‐dependent protein kinase II (Ca MKII ) in memory maintenance, and its influence on memory destabilization. After a brief review on Ca MKII and memory destabilization, we present critical pieces of evidence suggesting that Ca MKII activity increases retrieval‐induced memory destabilization. We then proceed to propose two potential molecular pathways to explain the association between Ca MKII activation and increased memory destabilization. This review will pinpoint gaps in our knowledge and discuss some ‘controversial’ observations, establishing the basis for new experiments on the role of Ca MKII in memory reconsolidation. The role of Ca MKII in memory destabilization is of great clinical relevance. Still, because of the lack of scientific literature on the subject, more basic science research is necessary to pursue this pathway as a clinical tool.