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The GABAergic system as a therapeutic target for Alzheimer's disease
Author(s) -
CalvoFlores Guzmán Beatriz,
Vinnakota Chitra,
Govindpani Karan,
Waldvogel Henry J.,
Faull Richard L.M.,
Kwakowsky Andrea
Publication year - 2018
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14345
Subject(s) - gabaergic , neuroscience , glutamatergic , inhibitory postsynaptic potential , disease , cholinergic , pathological , excitatory postsynaptic potential , medicine , alzheimer's disease , biology , glutamate receptor , pathology , receptor
Glutamatergic and cholinergic dysfunction are well‐attested features of Alzheimer's disease (AD), progressing with other pathological indices of the disorder and exacerbating neuronal and network dysfunction. However, relatively little attention has been paid to the inhibitory component of the excitatory/inhibitory (E/I) network, particularly dysfunction in the gamma‐aminobutyric acid (GABA) signaling system. There is growing evidence in support of GABAergic remodeling in the AD brain, potentially beginning in early stages of disease pathogenesis, and this could thus be a valid molecular target for drug development and pharmacological therapies. Several GABAergic drugs have been tested for efficacy in attenuating or reversing various features and symptoms of AD, and this could represent a novel path by which we might address the growing need for more effective and benign therapies.