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TRPC6 expression in neurons is differentially regulated by NR2A‐ and NR2B‐containing NMDA receptors
Author(s) -
Qu Zhongwei,
Wang Yuqing,
Li Xia,
Wu Lin,
Wang Yizheng
Publication year - 2017
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14215
Subject(s) - trpc6 , nmda receptor , glutamate receptor , neuroscience , biology , receptor , microbiology and biotechnology , chemistry , transient receptor potential channel , biochemistry
The expression of transient receptor potential canonical 6 (TRPC6) in central nervous system (CNS) is important for neuronal functions and certain neural disorders. However, the regulatory mechanism of TRPC6 expression in neurons is still obscure. In this study, we show that TRPC6 expression in the primary cultured cortical neurons is bidirectionally regulated by glutamate. Activation of NR2A‐containing NMDARs induces TRPC6 transcription through a calcineurin‐dependent pathway. In contrast, activation of NR2B‐containing NMDARs causes TRPC6 degradation through calpain. Thus, TRPC6 expression in neurons is regulated by glutamate in a bidirectional manner that is dependent on NR2A and NR2B.