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Issue Cover (October 2018)
Publication year - 2018
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14197
Subject(s) - endosome , gene knockdown , guanine nucleotide exchange factor , endocytic cycle , cover (algebra) , microbiology and biotechnology , biology , signal transduction , cell , genetics , gene , endocytosis , mechanical engineering , engineering , intracellular
Front cover: Background: The signaling pathways of ADP ribosylation factors (Arfs) regulated by a guanine nucleotide exchange factor, cytohesin‐2, are implicated in various neuronal functions through endosomal trafficking and actin cytoskeleton remodeling. Main findings: We identified pallidin as a novel interacting protein specific for cytohesin‐2 among the cytohesin family. Cytohesin‐2 colocalized with pallidin on a subset of early endosome antigen 1 (EEA1)‐positive early endosomes in cultured hippocampal neurons. Knockdown of either cytohesin‐2 or pallidin similarly affected the endocytic pathway. Furthermore, knockdown of pallidin had a stimulatory effect on dendritic extension via its coiled coil domain responsible for the interaction with cytohesin‐2. Implication: These results provide the first evidence for a functional relationship between cytohesin‐2 and pallidin in neurons. Image Content: This image taken by a pre‐embedding silver‐enhanced immunogold‐electron microscopic method shows the association of cytohesin‐2‐immunoreactive silver particles with the plasma membrane and endosomes in spines and dendritic shafts of hippocampal pyramidal neurons.Read the full article ‘ Pallidin is a novel interacting protein for cytohesin‐2 and regulates the early endosomal pathway and dendritic formation in neurons’ by A. Ito, M. Fukaya, S. Saegusa, E. Kobayashi, T. Sugawara, Y. Hara, J. Yamauchi, H. Okamoto, H. Sakagami ( J. Neurochem . 2018, vol. 147(2), pp. 153–177) on doi: 10.1111/jnc.14579