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Issue Cover (September 2018)
Publication year - 2018
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14191
Subject(s) - angiogenin , transfer rna , intracellular , rna , cover (algebra) , ribonuclease , cell , chemistry , biology , microbiology and biotechnology , cancer research , biochemistry , angiogenesis , gene , mechanical engineering , engineering
Front cover: Background: Transfer RNA (tRNA) plays a role in stress response programs involved in neurological diseases. Under cell stress conditions, intracellular tRNA is cleaved by a specific ribonuclease, angiogenin, generating tRNA‐derived stress‐induced RNA (tiRNA), which has potential cell protective effects. However, tiRNA generation in neuronal cells has not been fully elucidated. Main findings: We found that tiRNA is induced by various cell stresses, including in vitro ischemia‐reperfusion, via angiogenin‐mediated mechanism in PC12 neuronal cell. Implication: Detection of tiRNA could be used as a potential cell damage marker in neuronal cells. Image content: Cover image shows a micrographic image of the PC12 cells.Read the full article ‘ Stress‐induced tRNA cleavage and tiRNA generation in rat neuronal PC12 cells ’ by A. Elkordy, E. Mishima, K. Niizuma, Y. Akiyama, M. Fujimura, T. Tominaga, T. Abe ( J. Neurochem . 2018, vol. 146(5), pp. 560–569) on doi: 10.1111/jnc.14321