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Issue Cover (August 2018)
Publication year - 2018
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14189
Subject(s) - mitochondrial permeability transition pore , mitochondrion , microbiology and biotechnology , depolarization , neuroscience , homeostasis , programmed cell death , biology , chemistry , apoptosis , biophysics , biochemistry
Front cover: Background: Mitochondria play a critical role in neuronal physiology. Cyclophilin D (CypD) is a mitochondrial matrix protein. Transient opening of CypD‐mediated mitochondrial permeability transition (mPT) is a physiological event that regulates mitochondrial calcium homeostasis. Main findings: Genetic or pharmaceutical inhibition of CypD caused defective neuronal response to activity‐induced dendritic filopodiagenesis. Such inhibitory effect is closely associated with compromised flexibility of dendritic mitochondrial calcium regulation during neuronal depolarization, as well as the resultant changes in intra‐dendritic calcium homeostasis, calcium signaling activation, dendritic mitochondrial motility and redistribution. Implication: These findings suggest a physiological function of CypD in dendritic plasticity by acting as a fine‐tuner of mitochondrial calcium homeostasis. It should be with caution to use CypD inhibitors for the prevention of diseases. Image content: This confocal microscopy image shows the distribution of mitochondria in dendrites and dendritic protrusions. Mitochondria were visualized by Mitochondria targeted DsRed (red). Dendritic protrusions were determined by the staining of Actingreen 488 (green).Read the full article ‘ Cyclophilin D regulates neuronal activity‐induced filopodiagenesis by fine‐tuning dendritic mitochondrial calcium dynamics’ by S. Sui, J. Tian, E. Gauba, Q. Wang, L. Guo, H. Du (J. Neurochem. 2018, vol. 146(4), pp. 403–415) on doi: 10.1111/jnc.14484