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Issue Cover (August 2018)
Publication year - 2018
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14187
Subject(s) - nucleus accumbens , cart , sensitization , amphetamine , dopamine , behavioral sensitization , pharmacology , peptide , neuroscience , neurotransmitter , chemistry , receptor , psychology , medicine , biochemistry , mechanical engineering , engineering
Front cover: Background: Cocaine‐ and amphetamine‐regulated transcript (CART) peptide is a widely distributed neurotransmitter that attenuates cocaine‐induced locomotor activity when injected into the nucleus accumbens (NAc). Main findings: Here we show that cocaine administration enhances the phosphorylated Ca2+/calmodulin‐dependent protein kinaseIIα (pCaMKIIα)‐ D3 dopamine receptor (D3R) interaction in the NAc shell, while intra‐accumbal injection of CART peptide decreases cocaine‐induced locomotor sensitization. Implication: Therefore, we propose that CART peptide exerts its inhibitory effect on cocaine‐induced locomotor sensitization via inhibition of the pCaMKIIα‐D3R interaction, calcium influx and D3R signaling in the NAc shell, which could provide new evidence for the application of CART peptide to treat cocaine‐induced behavioral sensitivity. Image content: The image shows a immunofluorescence image of CaMKIIα‐GFP‐overexpressing NAc neurons (green) stained with pCaMKIIα antibodies (red), nuclei (DAPI, blue).Read the full article ‘ Cocaine‐ and amphetamine‐regulated transcript peptide in the nucleus accumbens shell inhibits cocaine‐induced locomotor sensitization to transient over‐expression of α‐Ca 2+ /calmodulin‐dependent protein kinase II’ by L. Xiong, Q. Meng, X. Sun, X. Lu, Q. Fu, Q. Peng, J. Yang, K.‐W. Oh, Z. Hu (J. Neurochem. 2018, vol. 146 (3), pp. 289–303) on doi: 10.1111/jnc.14289