Issue Cover (June 2018)

Front cover:Background: Alzheimer's disease (AD) is the most common chronic neurodegenerative disorder. Gamma‐aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There is growing evidence in support of GABAergic remodeling in the AD brain. Main findings: In this study we show alterations in the expression of the GABA type A receptor subunits α1, α2, α5, β2, β3 and γ2 subunits and preservation of the α3 and β1 subunits in the human AD hippocampus, subiculum, entorhinal cortex and superior temporal gyrus (STG) compared to healthy controls. Implication: these findings indicate that the expression of the GABAAR subunits shows brain region‐ and layer‐specific alterations in AD, and these changes could significantly influence and alter GABAAR function in the disease. Image content: The image shows GABAA receptor ·1 subunit (red) and NeuN (green) immunoreactivity in dentate gyrus region of the hippocampus of a healthy control case.Read the full article ‘ GABA A receptor subunit expression changes in the human Alzheimer's disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus' by A. Kwakowsky, B. Calvo‐Flores Guzmán, M. Pandya, C. Turner, H. J. Waldvogel, R. L. Faull (J. Neurochem. 2018, vol. 145 (5), pp. 374–392) on doi: 10.1111/jnc.14325