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Issue Cover (April 2018)
Publication year - 2018
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14173
Subject(s) - neurodegeneration , experimental autoimmune encephalomyelitis , multiple sclerosis , neuroscience , encephalomyelitis , myelin basic protein , white matter , astrocyte , biology , myelin , microbiology and biotechnology , central nervous system , pathology , immunology , medicine , disease , magnetic resonance imaging , radiology
Front cover:Background: N‐myc downstream‐regulated gene 2 (NDRG2) is a differentiation‐ and stress‐associated molecule that is predominantly expressed in astrocytes in the central nervous system. Main finding: In this study, we demonstrated that NDRG2 plays pathological roles in experimental autoimmune encephalomyelitis (EAE) most strongly at the step of neurodegeneration. NDRG2 regulates the expression of glutamate transporters through, at least in part, the PI3K/Akt signaling pathway. Implication: NDRG2‐expressiong astrocytes may be a novel target in MS and in other related diseases. Image Content: The image shows a confocal immunofluorescence microscopy image of SMI32 (damaged axons in the white matter) (green) and myelin basic protein (MBP) (red) in Ndrg2 -/- spinal cord after EAE.Read the full article ‘Ndrg2 deficiency ameliorates neurodegeneration in experimental autoimmune encephalomyelitis’ by T. M. Le, M. Takarada‐Iemata, H. M. Ta, J. Roboon, H. Ishii, T. Tamatani, Y. Kitao, T. Hattori, O. Hori ( J. Neurochem . 2018, vol. 145(2), pp. 139–153) ondoi: 10.1111/jnc.14294