Premium
Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases
Author(s) -
Roubroeks Janou A. Y.,
Smith Rebecca G.,
Hove Daniel L. A.,
Lun Katie
Publication year - 2017
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14148
Subject(s) - epigenetics , disease , alzheimer's disease , neuroscience , neurodegeneration , automatic summarization , biology , bioinformatics , computational biology , medicine , genetics , pathology , gene , computer science , artificial intelligence
Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of various neurodegenerative diseases. In this review, we discuss advances that have been made toward understanding the role of epigenetic processes in neurodegenerative disorders, with a particular focus on Alzheimer's disease, where the most extensive studies have been undertaken to date. We provide a brief overview of DNA modifications, followed by a summarization of studies of DNA modifications in Alzheimer's disease and other neurodegenerative diseases.