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The methylazoxymethanol acetate rat model: molecular and epigenetic effect in the developing prefrontal cortex
Author(s) -
Zhu Xiyu,
Gomes Felipe V.,
Grace Anthony A.
Publication year - 2017
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14133
Subject(s) - prefrontal cortex , neuroscience , epigenetics , psychology , chemistry , cognition , biochemistry , gene
This Editorial highlights an article by Gulchina and colleagues in the current issue of the Journal of Neurochemistry , in which the authors describe molecular and epigenetic changes in the developing prefrontal cortex of the rats exposed to methylazoxymethanol acetate (MAM). They found an NMDAR hypofunction present in the prefrontal cortex of juvenile MAM rats which was associated with abnormal epigenetic regulation of the Grin2b gene. These changes may be related to early cognitive impairments observed in MAM rats and schizophrenia patients.