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Cross‐sectional associations of cortical β‐amyloid with erythrocyte membrane long‐chain polyunsaturated fatty acids in older adults with subjective memory complaints
Author(s) -
Hooper Claudie,
De Souto Barreto Philipe,
Payoux Pierre,
Salabert Anne Sophie,
Guyonnet Sophie,
Andrieu Sandrine,
Vellas Bruno
Publication year - 2017
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.14062
Subject(s) - arachidonic acid , polyunsaturated fatty acid , linoleic acid , medicine , apolipoprotein e , endocrinology , apolipoprotein b , erythrocyte membrane , fatty acid , biology , biochemistry , chemistry , membrane , cholesterol , disease , enzyme
Abstract Omega‐3 (n‐3) and 6 (n‐6) polyunsaturated fatty acids ( PUFA s) have been associated with reduced cognitive decline in observational studies. Hence, we examined the cross‐sectional associations between cortical β‐amyloid (Aβ) and erythrocyte membrane PUFA s in 61 non‐demented elderly individuals reporting subjective memory complaints from the Multidomain Alzheimer Preventive Trial placebo arm. Cortical‐to‐cerebellar standard uptake value ratios were obtained using [ 18 F] florbetapir positron emission tomography. Fatty acids were measured in erythrocyte membranes by gas chromatography. Associations were explored using adjusted multiple linear regression models and were considered significant at p ≤ 0.005 after correction for multiple testing (10 comparisons). We found no significant associations between cortical Aβ and erythrocyte membrane PUFA s. The associations closest to significance after adjustment were those between Aβ and erythrocyte membrane arachidonic acid (without apolipoprotein E status adjustment: B‐coefficient, 0.03; CI , 0.01, 0.05; p = 0.02. Including Apolipoprotein E adjustment: B‐coefficient, 0.03; CI , 0.00, 0.06; p = 0.04) and Aβ and erythrocyte membrane linoleic acid (without apolipoprotein E status adjustment: B‐coefficient, −0.02; CI , −0.04, 0.00; p = 0.02. Including Apolipoprotein E adjustment: B‐coefficient, −0.02; CI , −0.04, 0.00; p = 0.09). Furthermore, the association between Aβ and erythrocyte membrane arachidonic acid seemed to be specific to Apolipoprotein E ε4 non‐carriers (B‐coefficient 0.03, CI : 0.00, 0.06, p = 0.03, n = 36). In contrast, no association was found between Aβ and erythrocyte membrane linoleic acid in Apolipoprotein E ε4 stratified analysis. Investigating the relationships between Aβ and PUFA s longitudinally would provide further evidence as to whether fatty acids, particularly arachidonic acid and linoleic acid, might modulate cognition through Aβ‐dependent mechanisms.