z-logo
Premium
Rab7A regulates tau secretion
Author(s) -
Rodriguez Lilia,
Mohamed NguyenVi,
Desjardins Alexandre,
Lippé Roger,
Fon Edward A,
Leclerc Nicole
Publication year - 2017
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.13994
Subject(s) - secretion , rab , biology , extracellular , endosome , microbiology and biotechnology , tau protein , intracellular , biochemistry , alzheimer's disease , medicine , gtpase , disease
Abstract The axonal microtubule‐associated protein TAU , involved in Alzheimer's disease ( AD ), can be found in the extracellular space where it could be taken up by neurons, an event that is believed to contribute to the propagation of tau pathology in the brain. Since the small GTP ase Rab7A is involved in the trafficking of endosomes, autophagosomes, and lysosomes, and RAB 7A gene expression and protein levels are up‐regulated in AD patients, we tested the hypothesis that Rab7A was involved in tau secretion. We previously reported that both primary cortical neurons and HeLa cells over‐expressing human TAU can release tau. Using these two cellular systems, we demonstrated that Rab7A regulates tau secretion. Upon Rab7A deletion, tau secretion was decreased. Consistent with this, the over‐expression of a dominant negative and a constitutively active form of Rab7A decreased and increased tau secretion, respectively. A partial co‐localization of tau and Rab7‐positive structures in both neurons and HeLa cells indicated that a late endosomal compartment could be involved in its secretion. Collectively, the present data indicate that Rab7A regulates tau secretion and therefore the up‐regulation of RAB 7A reported in AD , could contribute to the extracellular accumulation of pathological TAU species that could result in the propagation of tau pathology in the AD brain.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here