Issue Cover (November 2017)

Front cover: This Cover introduces the mini Review series ‘Beyond Amyloid’, in which the authors provide insights into various aspects of Alzheimer disease that go beyond the commonly discussed aspects of the disease. Guest editor: Christian Behl, Johannes Gutenberg University Mainz, Germany. Email: cbehl@uni-mainz.de . Sporadic Alzheimer's disease (AD) is a complex disease. Describing its totality is reminiscent of the story of the blind men trying to describe an elephant. As we probe the mysteries of the creature, sightless as to its full extent, we are drawn to its most obvious part – the giant trunk in the case of the elephant, β‐amyloid plaques in the case of AD. There are other blind men trying to be heard, however, as they describe other parts of the elephant and other features of the disease. Many functions decline with age (black line). Yet, our overemphasis on amyloid deposition (red line) has distracted us from the study of these other age‐related changes (gray matter – green line; white matter – purple line). In this issue, weblind men and women have joined together to describe the features of Alzheimer's disease that lie beyond the amyloid cascade hypothesis, and explore alternatives from the perspectives of evolution, bioenergetics, microtubules, and DNA damage in the brain.Read the full article ‘Re‐imagining Alzheimer's disease – the diminishing importance of amyloid and a glimpse of what lies ahead’ by K.‐H. Tse and K. Herrup ( J. Neurochem . 2017, vol. 143(4), pp. 432–444) on doi: 10.1111/jnc.14079