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Issue Cover (October 2017)
Publication year - 2017
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.13817
Subject(s) - growth cone , synaptogenesis , filopodia , neurite , context (archaeology) , neuroscience , neurogenesis , biology , amyloid precursor protein , hippocampal formation , microbiology and biotechnology , laminin , actin , alzheimer's disease , axon , pathology , medicine , genetics , disease , paleontology , in vitro , extracellular matrix
Front cover: The amyloid precursor protein (APP) plays a central role as a cell adhesion molecule in key events of neuronal development, such as migration, neurite outgrowth, growth cone pathfinding and synaptogenesis. Also, APP is overexpressed in Down syndrome individuals due to the extra copy of chromosome 21 and thus it might contribute to the down syndrome intellectual disabilities. The cover image shows the axonal growth cone from Ts65Dn hippocampal neuron (transgenic mice that develop a DS‐like condition) cultured on laminin and imaged by TIRF after labeling the actin filaments (green) and APP (red). Analysis performed with Ts65Dn mice revealed enrichment of APP in the cortex and within neurons, in the axonal growth cone. In this context, hippocampal pyramidal neurons derived from Ts65Dn mice and cultured on laminin substrate exhibit aberrant growth cones with large adhesive areas and abundant filopodia. This Review followed a CAEN Return Home Grant .Read the full article ‘The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system ’ by L. J. Sosa, A. Cáceres, S. Dupraz, M. Oksdath, S. Quiroga and A. Lorenzo ( J. Neurochem . 2017, vol. 143 (1), pp. 11–29) on doi: 10.1111/jnc.14122 Read the Editorial Highlight ‘A mobile APP for sharing contacts on your cell’ on doi: 10.1111/jnc.14115 .