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Issue Cover (August 2017)
Publication year - 2017
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.13809
Subject(s) - oligodendrocyte , biology , spinal cord , forebrain , immunocytochemistry , neuroscience , transplantation , pathology , myelin , central nervous system , medicine , endocrinology
Front cover: Rat spinal cord oligodendrocytes differentiating in vitro . A pure oligodendroglial lineage cell (OLC) culture from the rat neonatal spinal cord is stained for oligodendrocyte markers, O4 antigen (red) and galactocerebroside (green) by immunocytochemistry. Nuclei are stained with DAPI (Blue). By comparing pure oligodendrocyte cultures from rat spinal cords and forebrains, we demonstrated differing intrinsic biological properties between these two OLC groups originated from distinct CNS regions. Further understanding the regional differences of oligodendrocytes will help to improve treatments for demyelination in different CNS regions and to facilitate the development of stem cell‐derived OLCs for cell transplantation therapies for demyelination.Read the full article ‘Differing intrinsic biological properties between forebrain and spinal oligodendroglial lineage cells’ by M. Horiuchi, Y. Suzuki‐Horiuchi, T. Akiyama, A. Itoh, D. Pleasure, E. Carstens and T. Itoh ( J. Neurochem . 2017, vol. 142 (3), pp. 378–391) on doi: 10.1111/jnc.14074