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Issue Cover (May 2017)
Publication year - 2017
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.13797
Subject(s) - metabotropic glutamate receptor 5 , protein kinase c , metabotropic glutamate receptor , agonist , metabotropic glutamate receptor 1 , metabotropic receptor , glutamate receptor , neuroscience , receptor , chemistry , microbiology and biotechnology , biology , medicine , signal transduction
Front cover: Co‐expression of type 5 metabotropic glutamate receptor (mGluR5) and the protein kinase PKC epsilonin cultured rat cortical astrocytes. The illustration depicts the immunostaining of mGluR5 (green) and PKC epsilon (red) in mature astrocytes adopting a typical stellate morphology. This PKC isoform supports the oscillatory pattern in the intracellular signal triggered by mGluR5 agonists and contributes to preserve the receptor sensitivity upon repeated or sustained activations.Read the full article ‘PKC epsilon‐dependent calcium oscillations associated with metabotropic glutamate receptor 5 prevent agonist‐mediated receptor desensitization in astrocytes’ by M. Vergouts, P. J. Doyen, M. Peeters, R. Opsomer, T. Michiels and E. Hermans ( J. Neurochem . 2017, vol. 141 (3), pp. 387–399) on doi: 10.1111/jnc.14007