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Hippocampal PER 1: a circadian sentinel controlling RSK y activity during memory formation
Author(s) -
Yoo SeungHee,
EckelMahan Kristin
Publication year - 2016
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.13727
Subject(s) - hippocampal formation , circadian rhythm , neuroscience , hippocampus , chemistry , biology
Studies have demonstrated a pronounced dependence of memory formation on circadian time; however, the numerous mechanisms underlying this reliance are only beginning to be understood. While the 24‐h cellular clock controls various aspects of hippocampal memory formation, its consolidation in particular (i.e., its conversion from short‐term to long‐term memory), appears to be heavily dependent on circadian activity in hippocampal neurons. Hippocampal memory consolidation requires phosphorylation of the cAMP Response Element‐Binding protein, CREB, which upon phosphorylation promotes the transcription of genes necessary for long‐term memory formation. Rhythmic cAMP/ERK‐MAPK activity upstream of CREB is a necessary component. This Editorial highlights a study by Rawashdeh and coworkers, in which the authors establish the circadian clock gene Period1 (Per1) as a regulator of CREB phosphorylation in the mouse hippocampus, and thus reveal a functional link between circadian rhythms and learning efficiency. Read the highlighted article ‘Period1 gates the circadian modulation of memory‐relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK’ on page 731 .