Disrupted‐in‐schizophrenia‐1 as a broader link of glutamatergic transmission to schizophrenia impacts cerebral neurochemistry via the production of the ‘gliotransmitter’  d ‐serine, a  NMDA  receptor coagonist | Zendy

Wu Shengzhou | Zendy; Barger Steven W. | Zendy

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Disrupted‐in‐schizophrenia‐1 as a broader link of glutamatergic transmission to schizophrenia impacts cerebral neurochemistry via the production of the ‘gliotransmitter’ d ‐serine, a NMDA receptor coagonist

Author(s) -

Wu Shengzhou,

Barger Steven W.

Publication year - 2016

Publication title -

journal of neurochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.75

H-Index - 229

eISSN - 1471-4159

pISSN - 0022-3042

DOI - 10.1111/jnc.13699

Subject(s) - disc1 , glutamatergic , neurochemistry , schizophrenia (object oriented programming) , neuroscience , nmda receptor , neurotransmission , psychology , glutamate receptor , receptor , biology , psychiatry , genetics , gene , neurology

This Editorial highlights a study by Xia and coworkers in the current issue of the Journal of Neurochemistry, in which the authors reveal a possible mechanistic link between DISC1 (disrupted‐in‐schizophrenia‐1), a genetic risk factor for schizophrenia, and N ‐methyl‐ d ‐aspartate receptor (NMDAR) that is also linked with schizophrenia. The authors show that perturbed communication between DISC1 and NMDARs represents a hidden perpetrator for abnormal dendritic and synaptic maturation. Read the highlighted article ‘DISC1, astrocytes and neuronal maturation: a possible mechanistic link with implications for mental disorders’ on page 518 .

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