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FABP 1 in wonderland
Author(s) -
Prinetti Alessandro,
Mitro Nico
Publication year - 2016
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.13685
Subject(s) - cannabinoid receptor , endocannabinoid system , neuroscience , arachidonic acid , neurochemistry , cannabinoid , agonist , receptor , endogeny , psychology , pharmacology , medicine , biology , biochemistry , neurology , enzyme
Cannabinoid receptors hold a core position in the brain and control memory, cognition, movement, and pain sensitivity. sn ‐2 arachidonoylglycerol (2‐AG) activates neuronal cannabinoid receptors as a full agonist. The brain may rely on circulating arachidonic acid to synthesize endogenous cannabinoids. This Editorial highlights a study by Martin and coworkers in the current issue of the Journal of Neurochemistry in which the authors describe, for the first time, that liver acts as a pool of arachidonic acid that under certain conditions feeds the brain to produce endocannabinoids. Therapeutics affecting liver FABP1 levels should take into account that FABP1 represents a fatty acid reservoirs for the brain. Read the highlighted article “FABP‐1 gene ablation impacts brain endocannabinoid system in male mice” on page 407 .