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Targeting innate immunity for neurodegenerative disorders of the central nervous system
Author(s) -
Andreasson Katrin I.,
Bachstetter Adam D.,
Colonna Marco,
Ginhoux Florent,
Holmes Clive,
Lamb Bruce,
Landreth Gary,
Lee Daniel C.,
Low Donovan,
Lynch Marina A.,
Monsonego Alon,
O'Banion M. Kerry,
Pekny Milos,
Puschmann Till,
RussekBlum Niva,
Sandusky Leslie A.,
Selenica MajLinda B.,
Takata Kazuyuki,
Teeling Jessica,
Town Terrence,
Van Eldik Linda J.
Publication year - 2016
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.13667
Subject(s) - neuroinflammation , microglia , neuroscience , innate immune system , immune system , medicine , immunology , biology , inflammation
Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key signaling steps of innate immune activation hence represent promising therapeutic targets. This mini review series originated from the 4th Venusberg Meeting on Neuroinflammation held in Bonn, Germany, 7–9th May 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders, such as traumatic brain injury and Alzheimer disease, on the role of astrocytes and microglia, as well as technical developments that may help elucidate neuroinflammatory mechanisms and establish clinical relevance. In this meeting report, a brief overview of physiological and pathological microglia morphology is followed by a synopsis on PGE 2 receptors, insights into the role of arginine metabolism and further relevant aspects of neuroinflammation in various clinical settings, and concluded by a presentation of technical challenges and solutions when working with microglia and astrocyte cultures. Microglial ontogeny and induced pluripotent stem cell‐derived microglia, advances of TREM 2 signaling, and the cytokine paradox in Alzheimer's disease are further contributions to this article.Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key signaling steps of innate immune activation hence represent promising therapeutic targets. This mini review series originated from the 4th Venusberg Meeting on Neuroinflammation held in Bonn, Germany, 7–9th May 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders, such as traumatic brain injury and Alzheimer's disease, on the role of astrocytes and microglia, as well as technical developments that may help elucidate neuroinflammatory mechanisms and establish clinical relevance. In this meeting report, a brief overview on physiological and pathological microglia morphology is followed by a synopsis on PGE2 receptors, insights into the role of arginine metabolism and further relevant aspects of neuroinflammation in various clinical settings, and concluded by a presentation of technical challenges and solutions when working with microglia cultures. Microglial ontogeny and induced pluripotent stem cell‐derived microglia, advances of TREM2 signaling, and the cytokine paradox in Alzheimer's disease are further contributions to this article.