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miR‐186 in Alzheimer's disease: a big hope for a small RNA?
Author(s) -
Ben Halima Saoussen,
Siegel Gabriele,
Rajendran Lawrence
Publication year - 2016
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.13573
Subject(s) - neurochemistry , disease , regulator , neuroscience , neurology , alzheimer's disease , psychology , medicine , biology , gene , biochemistry
This Editorial highlights a study by Kim et al . in the current issue of Journal of Neurochemistry, in which the authors demonstrate that miR‐186 is a potent negative regulator of BACE1 and might be one of the molecular links between advanced brain aging and the increased risk for Alzheimer disease. Read the highlighted article ‘ miR‐186 is decreased in aged brain and suppresses BACE1 expression ’ on page 436.