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Regulation of neuronal migration, an emerging topic in autism spectrum disorders
Author(s) -
Reiner Orly,
Karzbrun Eyal,
Kshirsagar Aditya,
Kaibuchi Kozo
Publication year - 2016
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.13403
Subject(s) - neuronal migration , autism , autism spectrum disorder , neuroscience , brain development , disease , neurodevelopmental disorder , psychology , psychiatry , medicine , pathology
Abstract Autism spectrum disorders ( ASD ) encompass a group of neurodevelopmental diseases that demonstrate strong heritability, however, the inheritance is not simple and many genes have been associated with these disorders. ASD is regarded as a neurodevelopmental disorder, and abnormalities at different developmental stages are part of the disease etiology. This review provides a general background on neuronal migration during brain development and discusses recent advancements in the field connecting ASD and aberrant neuronal migration.We propose that neuronal migration impairment may be an important common pathophysiology in autism spectrum disorders (ASD). This review provides a general background on neuronal migration during brain development and discusses recent advancements in the field connecting ASD and aberrant neuronal migration.