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Issue Cover (November 2016)
Publication year - 2016
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.13342
Subject(s) - cd163 , haptoglobin , hemoglobin , neun , fetal hemoglobin , microglia , antibody , stroke (engine) , medicine , biology , immunology , immunohistochemistry , neuroscience , pathology , macrophage , fetus , pregnancy , biochemistry , inflammation , mechanical engineering , engineering , genetics , in vitro
Front cover: Merged image of culture of fetal mouse neurons stained with antibodies to NeuN (red) and CD163 (green), demonstrating neuronal localization of the hemoglobin‐haptoglobin receptor. Although CD163 expression is usually limited to monocytes/macrophages and microglia, recent observations indicate neuronal expression after neonatal hemorrhagic stroke. CD163+ neurons are more vulnerable to hemoglobin in the presence of haptoglobin. Therapies targeting CD163‐mediated hemoglobin uptake may be beneficial after neonatal stroke.Read the full article ‘ Haptoglobin increases the vulnerability of CD163‐expressing neurons to hemoglobin ’ by J. Chen‐Roetling and R. F. Regan ( J. Neurochem. 2016, vol. 139 (4), pp. 586–595) on doi: 10.1111/jnc.13720