Issue Cover (October 2016)

Front cover: The image shows immunocytochemical staining pattern for α‐synuclein (green) in SH‐SY5Y cells exposed to low‐dose (10 μM) MPP+ for 48 h. These cells reproduce slowly progressive death and α‐synuclein accumulation, which are typical features of Parkinson's disease (PD). The present study examined the effects of low‐dose MPP+ onautophagic processes and suggested the possibility that mild lysosomal damage may contribute to PD pathogenesis.Read the full article ‘ Mild MPP+ exposure impairs autophagic degradation through a novel lysosomal acidity‐independent mechanism ’ by M. Miyara, Y. Kotake, W. Tokunaga, S. Sanoh and S. Ohta ( J. Neurochem. 2016, vol. 139 (2), pp. 294–308) on doi: 10.1111/jnc.13700