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Issue Cover (October 2016)
Publication year - 2016
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.13338
Subject(s) - autophagy , pathogenesis , front cover , programmed cell death , chemistry , neuroscience , biology , microbiology and biotechnology , cover (algebra) , pathology , medicine , biochemistry , apoptosis , mechanical engineering , engineering
Front cover: The image shows immunocytochemical staining pattern for α‐synuclein (green) in SH‐SY5Y cells exposed to low‐dose (10 μM) MPP+ for 48 h. These cells reproduce slowly progressive death and α‐synuclein accumulation, which are typical features of Parkinson's disease (PD). The present study examined the effects of low‐dose MPP+ onautophagic processes and suggested the possibility that mild lysosomal damage may contribute to PD pathogenesis.Read the full article ‘ Mild MPP+ exposure impairs autophagic degradation through a novel lysosomal acidity‐independent mechanism ’ by M. Miyara, Y. Kotake, W. Tokunaga, S. Sanoh and S. Ohta ( J. Neurochem. 2016, vol. 139 (2), pp. 294–308) on doi: 10.1111/jnc.13700