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Issue Cover (January 2016)
Publication year - 2016
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.13300
Subject(s) - neurofibromin 1 , neurofibromatosis , mitosis , metaphase , suppressor , microtubule , biology , aneuploidy , glioblastoma , microbiology and biotechnology , chromosome , cancer research , genetics , cancer , gene
Front cover : The photomicrographs show both the co‐localization of the glioblastoma tumor suppressor neurofibromin with mitotic microtubules and normally congressed chromosomes at metaphase in astrocytes. Neurofibromin depletion leads to aberrant chromosome congression, a possible mechanism for the generation of CIN/aneuploidy in neurofibromatosis patients who have a 5‐fold increase incidence of glioblastoma.Read the full article ‘ Nuclear import mechanism of neurofibromin for localization on the spindle and function in chromosome congression ’ by X. Koliou, C. Fedonidis, T. Kalpachidou and D. Mangoura ( J. Neurochem. 2016, vol. 136 (1), pp. 78–91) on doi: 10.1111/jnc.13401