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Parkinson's disease, anxious depression and serotonin – zooming in on hippocampal neurogenesis
Author(s) -
Blum Robert,
Lesch KlausPeter
Publication year - 2015
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.13278
Subject(s) - subgranular zone , neurogenesis , dentate gyrus , neuroscience , serotonergic , doublecortin , hippocampal formation , parkinson's disease , neuroblast , psychology , depression (economics) , medicine , serotonin , disease , subventricular zone , biology , neural stem cell , stem cell , microbiology and biotechnology , receptor , macroeconomics , economics
This Editorial highlights a study by Deusser et al . (2015) published in this issue of J Neurochem. In a mouse model of Parkinson's disease (PD), the authors observed a topographically restricted reduction in serotonergic fibres in the subgranular zone of the dentate gyrus. This phenotype was observed close to the neurogenic niche and was accompanied by an impaired fluoxetine response of hippocampal neuroblasts. In conclusion, alpha‐synuclein inclusions in the serotonergic system may account for anxiety and depression symptoms in PD. DCX, doublecortin; GFAP, glial fibrillary acidic protein.