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An integrated energy plan for activated neurons
Author(s) -
Leloup Corinne
Publication year - 2015
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.13276
Subject(s) - microelectrode , neuroscience , multielectrode array , multicellular organism , extracellular , stimulus (psychology) , energy metabolism , computer science , chemistry , biology , biochemistry , psychology , cell , cognitive psychology , electrode , endocrinology
This Editorial highlights an ingenious study by Li and Freeman published in this issue of J. Neurochem . Accurately knowing the brain extracellular levels of the two main substrates, that is, glucose and lactate, while a well‐controlled and graded‐stimulus is applied, might be extremely useful to finely understand how these substrates are produced and used. To that end, the authors have designed a new approach that consists to record at the same time (100 ms resolution) extracellular glucose and lactate concentrations using electrochemical sensing microelectrodes equally distant from a microelectrode that registers the multicellular activity in response to light‐dependent stimuli (contrast levels from 10% to 80%). While this approach does, however, not evaluate the metabolic coupling between astrocytes and neurons, it proposes a new design which combined with molecular strategies specifically toward the glial or neuronal compartments will certainly help to demonstrate new distinctive features of this interesting question.