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Progressive brain metabolic changes under deep brain stimulation of subthalamic nucleus in parkinsonian rats
Author(s) -
Melon Christophe,
Chassain Carine,
Bielicki Guy,
Renou JeanPierre,
KerkerianLe Goff Lydia,
Salin Pascal,
Durif Franck
Publication year - 2015
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.13015
Subject(s) - subthalamic nucleus , striatum , deep brain stimulation , basal ganglia , neuroscience , dopamine , substantia nigra , parkinson's disease , microdialysis , putamen , glutamate receptor , psychology , medicine , dopaminergic , central nervous system , receptor , disease
Deep brain stimulation ( DBS ) of the subthalamic nucleus ( STN ) is an efficient neurosurgical treatment for advanced Parkinson's disease. Non‐invasive metabolic neuroimaging during the course of DBS in animal models may contribute to our understanding of its action mechanisms. Here, DBS was adapted to in vivo proton magnetic resonance spectroscopy at 11.7 T in the rat to follow metabolic changes in main basal ganglia structures, the striatum, and the substantia nigra pars reticulata (SNr). Measurements were repeated OFF and ON acute and subchronic (7 days) STN ‐ DBS in control and parkinsonian (6‐hydroxydopamine lesion) conditions. Acute DBS reversed the increases in glutamate, glutamine, and GABA levels induced by the dopamine lesion in the striatum but not in the SN r. Subchronic DBS normalized GABA in both the striatum and SN r, and glutamate in the striatum. Taurine levels were markedly decreased under subchronic DBS in the striatum and SN r in both lesioned and unlesioned rats. Microdialysis in the striatum further showed that extracellular taurine was increased. These data reveal that STN ‐ DBS has duration‐dependent metabolic effects in the basal ganglia, consistent with development of adaptive mechanisms. In addition to counteracting defects induced by the dopamine lesion, prolonged DBS has proper effects independent of the pathological condition.Non‐invasive metabolic neuroimaging might be useful to understand the physiological mechanisms of deep brain stimulation (DBS). Here, we demonstrate the feasibility of repeated high‐field proton magnetic resonance spectroscopy of basal ganglia structures under subthalamic nucleus DBS in control and parkinsonian rats. Results show that DBS has both rapid and delayed effects either dependent or independent of disease state.