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Issue Cover (October 2015)
Publication year - 2015
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.12905
Subject(s) - amyotrophic lateral sclerosis , immunocytochemistry , glial fibrillary acidic protein , astrocyte , sod1 , motor neuron , neuroscience , microbiology and biotechnology , biology , genetically modified mouse , pathology , transgene , medicine , immunology , disease , endocrinology , central nervous system , biochemistry , gene , immunohistochemistry , spinal cord
Front cover : There is extensive evidence of the crucial contribution of astrocytes in motor neuron degeneration in ALS. The expression of SOD1 with G93A mutation induces the activation of these cells in vitro. Immunocytochemistry with anti‐ glial fibrillary acidic protein (GFAP) antibody shows thick processes in transgenic cultured astrocytes that become toxic to motor neurons.Read the full article ‘ Lack of TNF‐alpha receptor type 2 protects motor neurons in a cellular model of amyotrophic lateral sclerosis and in mutant SOD1 mice but does not affect disease progression ’ by M. Tortarolo, A. Vallarola, D. Lidonnici, E. Battaglia, F. Gensano, G. Spaltro, F. Fiordaliso, A. Corbelli, S. Garetto, E. Martini, L. Pasetto, M. Kallikourdis, V. Bonetto and C. Bendotti ( J. Neurochem. 2015, vol. 135 (1), pp. 109–124) on doi: 10.1111/jnc.13154