Premium
Issue Cover (August 2015)
Publication year - 2015
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.12893
Subject(s) - lysophosphatidic acid , g protein coupled receptor , receptor , neuroscience , growth cone , anatomy , biology , microbiology and biotechnology , chemistry , biochemistry , axon
Front cover : Lysophosphatidic acid (LPA) is a signaling molecule that binds to six known G protein‐coupled receptors (GPCRs), LPA 1 to LPA 6 . LPA evokes several responses in the CNS including cortical development and folding, growth of the axonal cone and its retraction process. We used functional [35S]GTPγS autoradiography to verify the anatomical distribution of LPA 1 binding sites in adult rodent and human brain. The autoradiographic image shows [35S]GTPγS basal binding in a sagittal section of rat central nervous system (CNS) stimulated by LPA (10‐5 M).Read the full article ‘ Anatomical location of LPA 1 activation and LPA phospholipid precursors in rodent and human brain ’ by E. González de San Román, I. Manuel, M. T. Giralt, J. Chun, G. Estivill‐Torrús, F. Rodríguez de Fonseca, L. J. Santín, I. Ferrer and R. Rodríguez‐Puertas (J. Neurochem. 2015, vol. 134 (3), pp. 471–485) on doi: 10.1111/jnc.13112