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Sialyltransferase ST 3Gal IV deletion protects against temporal lobe epilepsy
Author(s) -
Srimontri Paitoon,
Endo Shogo,
Sakamoto Toshiro,
Nakayama Yoshiaki,
Kurosaka Akira,
Itohara Shigeyoshi,
Hirabayashi Yoshio,
Kato Keiko
Publication year - 2014
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.12838
Subject(s) - epilepsy , sialyltransferase , temporal lobe , chemistry , biochemistry , microbiology and biotechnology , neuroscience , biology , enzyme
Abstract Temporal lobe epilepsy (TLE) often becomes refractory, and patients with TLE show a high incidence of psychiatric symptoms, including anxiety and depression. Therefore, it is necessary to identify molecules that were previously unknown to contribute to epilepsy and its associated disorders. We previously found that the sialyltransferase ST3Gal IV is up‐regulated within the neural circuits through which amygdala‐kindling stimulation propagates epileptic seizures. In contrast, this study demonstrated that kindling stimulation failed to evoke epileptic seizures in ST3Gal IV‐deficient mice. Furthermore, approximately 80% of these mice failed to show tonic–clonic seizures with stimulation, whereas all littermate wild‐type mice showed tonic–clonic seizures. This indicates that the loss of ST3Gal IV does not cause TLE in mice. Meanwhile, ST3Gal IV‐deficient mice exhibited decreased acclimation in the open field test, increased immobility in the forced swim test, enhanced freezing during delay auditory fear conditioning, and sleep disturbances. Thus, the loss of ST3Gal IV modulates anxiety‐related behaviors. These findings indicate that ST3Gal IV is a key molecule in the mechanisms underlying anxiety – a side effect of TLE – and may therefore also be an effective target for treating epilepsy, acting through the same circuits.Temporal lobe epilepsy (TLE) often becomes refractory, and the patients show a high incidence of psychiatric symptoms, including anxiety and depression. We indicate that the loss of sialyltransferase ST3Gal IV protects against TLE in mice, while exhibits decreased acclimation in the open field, increased immobility in the forced swim, and enhanced freezing during delay auditory fear conditioning. These findings indicate that ST3Gal IV is an effective target for treating epilepsy, and is a key molecule in the mechanisms underlying anxiety.