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Insights into the physiological function of the β‐amyloid precursor protein: beyond Alzheimer's disease
Author(s) -
Dawkins Edgar,
Small David H.
Publication year - 2014
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.12675
Subject(s) - amyloid precursor protein , neurite , neuroscience , p3 peptide , microbiology and biotechnology , alzheimer's disease , biology , signal transduction , amyloid (mycology) , neural stem cell , biochemistry of alzheimer's disease , in vitro , stem cell , disease , biochemistry , medicine , pathology , botany
The β‐amyloid precursor protein ( APP ) has been extensively studied for its role as the precursor of the β‐amyloid protein (Aβ) of Alzheimer's disease. However, the normal function of APP remains largely unknown. This article reviews studies on the structure, expression and post‐translational processing of APP , as well as studies on the effects of APP in vitro and in vivo . We conclude that the published data provide strong evidence that APP has a trophic function. APP is likely to be involved in neural stem cell development, neuronal survival, neurite outgrowth and neurorepair. However, the mechanisms by which APP exerts its actions remain to be elucidated. The available evidence suggests that APP interacts both intracellularly and extracellularly to regulate various signal transduction mechanisms.This article reviews studies on the structure, expression and post‐translational processing of β‐amyloid precursor protein (APP), as well as studies on the effects of APP in vitro and in vivo. We conclude that the published data provide strong evidence that APP has a trophic function. APP is likely to be involved in neural stem cell development, neuronal survival, neurite outgrowth and neurorepair. However, the mechanisms by which APP exerts its actions remain to be elucidated. The available evidence suggests that APP interacts both intracellularly and extracellularly to regulate various signal transduction mechanisms.