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Specific changes of sulfatide levels in individuals with pre‐clinical Alzheimer's disease: an early event in disease pathogenesis
Author(s) -
Cheng Hua,
Wang Miao,
Li JianLiang,
Cairns Nigel J.,
Han Xianlin
Publication year - 2013
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.12368
Subject(s) - neuropathology , glycerophospholipid , pathogenesis , ceramide , disease , sphingolipid , alzheimer's disease , lipidomics , biology , medicine , pathology , neuroscience , bioinformatics , biochemistry , membrane , phospholipid , apoptosis
To explore the hypothesis that alterations in cellular membrane lipids are present at the stage of pre‐clinical Alzheimer's disease ( AD ) (i.e., cognitively normal at death, but with AD neuropathology), we performed targeted shotgun lipidomics of lipid extracts from post‐mortem brains of subjects with pre‐clinical AD . We found sulfatide levels were significantly lower in subjects with pre‐clinical AD compared to those without AD neuropathology. We also found that the level of ethanolamine glycerophospholipid was marginally lower at this stage of AD , whereas changes of the ceramide levels were undetectable with the available samples. These results indicate that cellular membrane defects are present at the earliest stages of AD pathogenesis and also suggest that sulfatide loss is among the earliest events of AD development, while alterations in the levels of ethanolamine glycerophospholipid and ceramide occur relatively later in disease.