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MicroRNA profiling in the mouse hypothalamus reveals oxytocin‐regulating microRNA
Author(s) -
Choi JiWoong,
Kang SungMin,
Lee Youngkyun,
Hong SuHyung,
Sanek Nicholas A.,
Young W. Scott,
Lee HeonJin
Publication year - 2013
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1111/jnc.12308
Subject(s) - microrna , biology , oxytocin , gene silencing , hypothalamus , gene , regulation of gene expression , gene expression , gene expression profiling , microbiology and biotechnology , genetics , neuroscience
Oxytocin (Oxt), produced in the hypothalamic paraventricular and supraoptic nuclei for transport to and release from the posterior pituitary, was originally discovered through its role in lactation and parturition. Oxt also plays important roles in the central nervous system by influencing various behaviors. MicroRNAs (miRNAs), endogenous regulators of many genes, are a class of small non‐coding RNAs that mediate post‐transcriptional gene silencing. We performed miRNA expression profiling of the mouse hypothalamus by deep sequencing. Among the sequenced and cross‐mapped small RNAs, expression of known miRNAs and unknown miRNAs candidates were analyzed. We investigated in detail one miRNA, miR‐24, and found that it is a novel regulator of Oxt and controls both transcript and peptide levels of Oxt. These results provide insights into potential neurohypophysial hormone regulation mediated by miRNAs.