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Metabolic Predictors of High‐ vs. Low‐Oxytocin Requirements During Labor Induction
Author(s) -
Carlson Nicole S.,
Frediani Jennifer K.,
Corwin Elizabeth J.,
Dunlop Anne,
Jones Dean
Publication year - 2020
Publication title -
journal of midwifery and women's health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.543
H-Index - 62
eISSN - 1542-2011
pISSN - 1526-9523
DOI - 10.1111/jmwh.13181
Subject(s) - oxytocin , labor induction , cervical dilation , pregnancy , medicine , gestational age , gestation , obstetrics , endocrinology , biology , genetics
The purpose of this study was to evaluate differences in the metabolic pathways activated in late‐pregnancy serum samples among African American women who went on to have term (≥37 weeks) labor induction requiring high total oxytocin doses to complete first‐stage labor compared to those in similar women with low‐oxytocin labor inductions. Methods Case–control study (N = 27 women with labor induction with successful cervical ripening: 13 requiring the highest total doses of synthetic oxytocin to progress from 4‐ to 10‐cm cervical dilation and 14 requiring the lowest total doses) with groups balanced on parity and gestational age. Serum samples obtained between 24 and 30 weeks’ gestation were analyzed using ultra‐high‐resolution metabolomics. Differentially expressed metabolites between high‐oxytocin induction cases and low‐oxytocin induction comparison subjects were evaluated using linear regression with xmsPANDA. Metabolic pathways analysis was conducted using Mummichog Version 2.0, with discriminating metabolites annotated using xMSannotator Version 1.3. Results Labor processes were similar by group with the exception that cases received over 6 times more oxytocin between 4‐ and 10‐cm cervical dilation than comparison women. Induction requiring high total doses of synthetic oxytocin was associated with late‐pregnancy serum levels of metabolites from the linoleate and fatty acid activation pathways in term, African American women. Discussion Serum levels of several lipid metabolites predicted more complicated labor induction involving higher doses of synthetic oxytocin to complete first‐stage labor. Further investigation in larger, more diverse cohorts of women is needed to identify potential targets to prevent failed labor induction. Reprinted with permission. Carlson NS, Frediani JK, Corwin EJ, Dunlop A, Jones D., Metabolic pathways associated with term labor in African‐American women. Biol Res Nurs . 2020;22(2):157‐168.