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Evolution of SIVmac239 following serial passaging in humanized mice
Author(s) -
Curlin James Z.,
Schmitt Kimberly,
RemlingMulder Leila,
Morrison Jared,
Baczenas John J.,
Tibbits Corina Valencia,
Goff Kelly,
O'Connor Shelby,
Stenglein Mark,
Marx Preston,
Akkina Ramesh
Publication year - 2022
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12614
Subject(s) - humanized mouse , biology , serial passage , transmission (telecommunications) , virology , rhesus macaque , mutation , immunology , microbiology and biotechnology , genetics , virus , immune system , computer science , gene , telecommunications
Abstract Serial passage of SIVmac239 allows for greater understanding of the genetic changes necessary for cross‐species transmission of primate lentiviruses into humans. Using humanized mice, we show that adaptive mutations continue to accumulate in SIVmac239 during four serial passages, with persistent CD4 + T cell decline and increases in plasma viral loads.