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Feasibility of combined upper and lower gastrointestinal endoscopic biopsy in the common marmoset ( Callithrix jacchus ) to evaluate gastrointestinal diseases
Author(s) -
Heilmann Romy M.,
McIntosh Jenny,
Acke Els,
Reitemeier Susanne,
Pfannkuche Helga,
Erdmann Sabrina,
Roedler Frauke S.,
Einspanier Almuth
Publication year - 2022
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12580
Subject(s) - callithrix , marmoset , esophagogastroduodenoscopy , medicine , colonoscopy , duodenum , gastrointestinal tract , gastroenterology , biopsy , pathology , endoscopy , biology , colorectal cancer , cancer , paleontology
Background Chronic gastroenteropathies, including gluten sensitivity and marmoset wasting syndrome, frequently occur in captive colonies of common marmosets ( Callithrix jacchus ). Early identification and diagnosis of affected animals are desirable. Endoscopic examination of the colon in marmosets is described, but the small intestine can harbor significant mucosal lesions not representing those in the colon. Evaluating the small intestine currently requires invasive surgical biopsies due to the small patient size, carrying a risk of severe complications. Methods Endoscopic intubation and multisite biopsy of the duodenum/proximal jejunum are demonstrated in 10 marmosets under general anesthesia. Results Esophagogastroduodenoscopy with colonoscopy efficiently aid in examining the gastrointestinal tract and obtaining an antemortem histologic diagnosis in marmosets with chronic gastrointestinal signs. Conclusions This minimally invasive technique is feasible in marmosets. Future investigations into the pathogenesis of chronic gastroenteropathies will benefit from these data, leading to improved animal welfare and better individual and colony health management.