Age‐related cognitive impairment is associated with low serum concentrations of testosterone and CSF levels of amyloid beta 42 in male cynomolgus monkeys ( Macaca fascicularis ) | Zendy

Darusman Huda Shalahudin | Zendy; Li Wern Tan | Zendy; Sajuthi Dondin | Zendy; Schapiro Steven J. | Zendy; Hau Jann | Zendy

Premium

Age‐related cognitive impairment is associated with low serum concentrations of testosterone and CSF levels of amyloid beta 42 in male cynomolgus monkeys ( Macaca fascicularis )

Author(s) -

Darusman Huda Shalahudin,

Li Wern Tan,

Sajuthi Dondin,

Schapiro Steven J.,

Hau Jann

Publication year - 2021

Publication title -

journal of medical primatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.31

H-Index - 42

eISSN - 1600-0684

pISSN - 0047-2565

DOI - 10.1111/jmp.12536

Subject(s) - testosterone (patch) , medicine , cerebrospinal fluid , endocrinology , amyloid (mycology) , adult male , memory impairment , dementia , cognitive impairment , physiology , psychology , cognition , neuroscience , pathology , disease

Aged memory‐impaired cynomolgus monkeys had significantly lower levels of cerebrospinal amyloid (Aβ 42 ) and serum testosterone compared with young animals and non–memory‐impaired controls. Our findings confirm similar findings in the human and substantiate the usefulness of the cynomolgus monkey as a spontaneous model for aging‐associated senile dementia of the Alzheimer type.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research