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Age‐related cognitive impairment is associated with low serum concentrations of testosterone and CSF levels of amyloid beta 42 in male cynomolgus monkeys ( Macaca fascicularis )
Author(s) -
Darusman Huda Shalahudin,
Li Wern Tan,
Sajuthi Dondin,
Schapiro Steven J.,
Hau Jann
Publication year - 2021
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12536
Subject(s) - testosterone (patch) , medicine , cerebrospinal fluid , endocrinology , amyloid (mycology) , adult male , memory impairment , dementia , cognitive impairment , physiology , psychology , cognition , neuroscience , pathology , disease
Aged memory‐impaired cynomolgus monkeys had significantly lower levels of cerebrospinal amyloid (Aβ 42 ) and serum testosterone compared with young animals and non–memory‐impaired controls. Our findings confirm similar findings in the human and substantiate the usefulness of the cynomolgus monkey as a spontaneous model for aging‐associated senile dementia of the Alzheimer type.