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Inherited OKT4 epitope deficiency in a Chinese rhesus macaque
Author(s) -
Liu BenBo,
Zhao MingLiang,
Wang Yun,
Hu ZhengFei,
Zheng YongTang,
Tian RenRong
Publication year - 2021
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12526
Subject(s) - epitope , biology , genetics , coding region , macaque , linear epitope , population , arginine , virology , amino acid , antibody , gene , medicine , paleontology , environmental health
OKT4 is an important epitope of the CD4 molecular. Amino acid mutations in the CD4V3 region result in deficiency of the OKT4 epitope in human. Here, we firstly reported a case of hereditary deficiency of OKT4 epitope in an inbred Chinese rhesus macaque family. This epitope deficiency is due to cytosine to thymine transition and homozygote at the nucleotide position 793 of CD4 coding sequences, which leads to the replace of arginine at 265th position of CD4 molecule by tryptophan. The results reveal that OKT4 epitope deficiency is a very old phenotype and may be parentally inherited, and emphasize the importance of avoiding inbreeding in primate population breeding.