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Safety and immunogenicity of 17DD attenuated yellow fever vaccine in howler monkeys ( Alouatta spp.)
Author(s) -
Tavares da Silva Fernandes André,
Moreira Silvia Bahadian,
Gaspar Luciane Pinto,
Simões Marisol,
Cajaraville Ana Carolina dos Reis Albuquerque,
Pereira Renata Carvalho,
Gomes Mariana Pierre de Barros,
Linhares José Henrique Rezende,
Santos Vanessa de Oliveira,
Santos Renata Tourinho,
Amorim Juliana Fernandes,
Barros Tamiris Azamor da Costa,
Melgaço Juliana Gil,
Silva Andréa Marques Vieira,
Fernandes Camilla Bayma,
Tubarão Luciaeves,
Silva Jane,
Caride Elena Cristina,
Borges Maria Beatriz,
Guimarães Rosane Cuber,
Marchevsky Renato Sérgio,
Lima Sheila Maria Barbosa,
Ano Bom Ana Paula Dinis,
Neves Patrícia Cristina da Costa,
Pissinatti Alcides,
Freire Marcos da Silva
Publication year - 2021
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12501
Subject(s) - immunogenicity , viremia , yellow fever , immunization , vaccination , virology , yellow fever vaccine , outbreak , biology , immunology , antibody , virus
Background Alouatta spp. are highly susceptible to yellow fever (YF) infection and develop an often fatal disease. The threat posed by an outbreak started in 2016 leads us to investigate vaccination as a potential tool in preventing YF in non‐human primates (NHP). Methods Susceptible howler monkeys were immunized with three different concentrations of the human Brazilian commercial YF17DD vaccine. Post‐vaccination viremia/RNAemia, immunogenicity, and safety were characterized. Results The vaccine did not produce YF clinical manifestations in any of the NHPs. After immunization, all animals seroconverted demonstrating the ability of the YF vaccine to induce humoral response in Alouatta species. Conclusions The present work has demonstrated the safe and immunogenic profile of the existing YF 17DD vaccine in howler monkeys. This knowledge may support further studies with other susceptible monkey species and provide a possible solution for controlling epizootics and preventing the devastation of endangered species.