Evolution of SIVsm in humanized mice towards HIV‐2 | Zendy

Curlin James | Zendy; Schmitt Kimberly | Zendy; RemlingMulder Leila | Zendy; Moriarty Ryan | Zendy; Goff Kelly | Zendy; O’Connor Shelby | Zendy; Stenglein Mark | Zendy; Marx Preston | Zendy; Akkina Ramesh | Zendy

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Evolution of SIVsm in humanized mice towards HIV‐2

Author(s) -

Curlin James,

Schmitt Kimberly,

RemlingMulder Leila,

Moriarty Ryan,

Goff Kelly,

O’Connor Shelby,

Stenglein Mark,

Marx Preston,

Akkina Ramesh

Publication year - 2020

Publication title -

journal of medical primatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.31

H-Index - 42

eISSN - 1600-0684

pISSN - 0047-2565

DOI - 10.1111/jmp.12486

Subject(s) - humanized mouse , biology , virulence , virology , transmission (telecommunications) , virus , mutation , genetics , gene , immune system , electrical engineering , engineering

Through the accumulation of adaptive mutations, HIV‐2 originated from SIVsm. To identify these evolutionary changes, a humanized mouse model recapitulated the process that likely enabled this cross‐species transmission event. Various adaptive mutations arose, as well as increased virulence and CD4 + T‐cell decline as the virus was passaged in humanized mice.

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