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Evolution of SIVsm in humanized mice towards HIV‐2
Author(s) -
Curlin James,
Schmitt Kimberly,
RemlingMulder Leila,
Moriarty Ryan,
Goff Kelly,
O’Connor Shelby,
Stenglein Mark,
Marx Preston,
Akkina Ramesh
Publication year - 2020
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12486
Subject(s) - humanized mouse , biology , virulence , virology , transmission (telecommunications) , virus , mutation , genetics , gene , immune system , electrical engineering , engineering
Through the accumulation of adaptive mutations, HIV‐2 originated from SIVsm. To identify these evolutionary changes, a humanized mouse model recapitulated the process that likely enabled this cross‐species transmission event. Various adaptive mutations arose, as well as increased virulence and CD4 + T‐cell decline as the virus was passaged in humanized mice.