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Mimicking SIV chimpanzee viral evolution toward HIV‐1 during cross‐species transmission
Author(s) -
Schmitt Kimberly,
Curlin James,
RemlingMulder Leila,
Moriarty Ryan,
Goff Kelly,
O’Connor Shelby,
Stenglein Mark,
Marx Preston,
Akkina Ramesh
Publication year - 2020
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12485
Subject(s) - biology , virology , viral load , viral evolution , transmission (telecommunications) , genome , humanized mouse , simian immunodeficiency virus , adaptation (eye) , human immunodeficiency virus (hiv) , genetics , evolutionary biology , gene , immune system , neuroscience , electrical engineering , engineering
HIV‐1 evolved from SIV during cross‐species transmission events, though viral genetic changes are not well understood. Here, we studied the evolution of SIVcpzLB715 into HIV‐1 Group M using humanized mice. High viral loads, rapid CD4 + T‐cell decline, and non‐synonymous substitutions were identified throughout the viral genome suggesting viral adaptation.