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Evaluation of anaesthetic and cardiorespiratory effects after intramuscular administration of alfaxalone alone, alfaxalone‐ketamine and alfaxalone‐butorphanol‐medetomidine in common marmosets ( Callithrix jacchus )
Author(s) -
MiyabeNishiwaki Takako,
Miwa Miki,
Konoike Naho,
Kaneko Akihisa,
Ishigami Akiyo,
Natsume Takayoshi,
MacIntosh Andrew J. J.,
Nakamura Katsuki
Publication year - 2020
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12482
Subject(s) - butorphanol , medetomidine , atipamezole , anesthesia , ketamine , medicine , heart rate , blood pressure
Background Anaesthesia is often required in common marmosets undergoing various procedures. The aim of this study was to evaluate anaesthetic and cardiopulmonary effects of alfaxalone, alfaxalone‐ketamine and alfaxalone‐butorphanol‐medetomidine in common marmosets. Methods The following treatments were repeatedly administered to seven female common marmosets: Treatment A, alfaxalone (12 mg kg ‐1 ) alone; treatment AK, alfaxalone (1 mg animal −1 ) plus ketamine (2.5 mg animal −1 ); treatment AMB, alfaxalone (4 mg kg −1 ), medetomidine (50 µg kg −1 ) plus butorphanol (0.3 mg kg −1 ); and treatment AMB‐Ati, AMB with atipamezole at 45 minutes. Results and Conclusions Marmosets became laterally recumbent and unresponsive for approximately 30 minutes in A and AK and for approximately 60 minutes in AMB. The animals showed rapid recovery following atipamezole injection in AMB‐Ati. The decrease in heart rate and SpO 2 was significantly greater in AMB compared to A and AK. Oxygen supplementation, anaesthetic monitors and atipamezole should be available especially when AMB is administered.