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Comparison of midazolam and butorphanol combined with ketamine or dexmedetomidine for chemical restraint in howler monkeys ( Alouatta guariba clamitans ) for vasectomy
Author(s) -
Fagundes Natália,
Castro Marina Lopes,
Silva Renata Andrade,
De Lima Marcos Paulo Antunes,
Braga Carolina Silveira,
Dos Santos Eduardo Almeida Ruivo,
Oliveira Moira Ansolch,
Mattoso Claudio Roberto Scabelo,
Pimenta Eutálio Luiz Mariani,
Beier Suzane Lilian
Publication year - 2020
Publication title -
journal of medical primatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 42
eISSN - 1600-0684
pISSN - 0047-2565
DOI - 10.1111/jmp.12467
Subject(s) - butorphanol , dexmedetomidine , medicine , sedation , midazolam , anesthesia , ketamine
Abstract Background This study evaluated and compared cardiorespiratory and blood gas parameters, as well as sedation, analgesia and recovery of two protocols: ketamine (10 mg/kg) or dexmedetomidine (10 μg/kg), with midazolam (0.5 mg/kg) and butorphanol (0.3 mg/kg), IM (KBM and DBM, respectively) in brown howler monkeys ( Alouatta guariba clamitans ). Material and methods Twelve brown howler monkeys were selected in two groups and evaluated for cardiorespiratory parameters and sedation, from 5‐30 minutes after latency. Blood gas and arterial lactate were taken at 5 and 30 minutes. In the end, time and quality of recovery were evaluated. Results The HR in DBM group was significantly lower at all times. The sedation score was higher in DBM. Recovery in DBM was faster. All animals had moderate hypoxaemia. Conclusion Both protocols produce satisfactory anaesthesia and analgesia, but DBM provides deeper sedation with faster recovery. Oxygen supplementation is recommended in both due to hypoxaemia.